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Anti-Phospho-CHK2 (Ser516)抗体

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产品名称: Anti-Phospho-CHK2 (Ser516)抗体
产品型号: Phospho-CHK2 (Ser516)抗体
产品展商: 科研抗体
产品文档: 无相关文档

简单介绍

Anti-Phospho-CHK2 (Ser516)抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-Phospho-CHK2 (Ser516)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。


Anti-Phospho-CHK2 (Ser516)抗体  的详细介绍
Rabbit  Anti-Phospho-CHK2 (Ser516)
Cat. Number:
YB-5257R
Quantity size:
0.1ml
Concentration:
Anti-Phospho-CHK2 (Ser516)抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocksAnti-Phospho-CHK2 (Ser516)抗体 and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Also known as:
Anti-Phospho-CHK2 (Ser516)抗体Chk2 (phospho S516); p-Chk2 (phospho S516); Chk2 (Phospho-Ser516); bA444G7; CHK2 checkpoint homolog; CHK2_HUMAN; Serine/threonine-protein kinase Chk2; CDS 1; CDS1; Checkpoint kinase 2; Checkpoint like protein CHK2; Chek 2; Chek2; Chk 2; CHK2 checkpoint homolog (S. pombe); CHK2 checkpoint homolog; HuCds 1; HuCds1; LFS 2; LFS2; PP1425; RAD 53; RAD53; Rad53 homolog; Serine/threonine protein kinase Chk2.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, .
Immunogen:Anti-Phospho-CHK2 (Ser516)抗体 KLH conjugated Synthesised phosphopeptide derived from human.
Predicted Molecular Weight: 61kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. Anti-Phospho-CHK2 (Ser516)抗体
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